Ye Zhang

Lab

The Zhang Lab

Research Areas

• Nanobioengineering
• Fluid Mechanics
• Biomaterials
• Translational Cancer Research

Areas of Interest

• Single-cell biophysical profiling in cancer, immunity & microbiome
• High-throughput microfluidic cell sorting
• Digital microfluidics for multiplexed nucleic diagnostics
• Single-cell multi-omics
• Translational biomarkers for diagnostics & therapy selection 

Education

• Massachusetts Institute of Technology: Postdoctoral Researcher, Koch Institute for Integrative Cancer Research, 2019-2025
• Johns Hopkins University: Ph.D., Biomedical Engineering, 2019
• Tsinghua University: B.E., Biomedical Engineering, 2011

Awards and Recognitions

• Koch Institute Marlena Felter Bradford Research Travel Award, 2025
• Best Lightning Talk Prize at Physical Sciences -Oncology Investigators Meeting, 2024
• Koch Institute Convergence Scholar, 2020-2021
• Goldman Sachs Global Leaders Program Scholarship, 2009

Selected Publications

Y. Zhang, L. Debaize, A. Langenbucher, J. Weekes, I. Vogiatzi, T. P. Miettinen, M. Zhang, E. Sumpena, H. Liu, S. M. Duquette, L. Hackett, J. Zhang, S. Baghiyan, R. A. Redd, M. Aryee, M. S. Davids, A. I. Kim, C. E. Ryan, D. M. Weinstock, S. R. Manalis, M. A. Murakami. Integrating Single-Cell Biophysical and Transcriptomic Features to Resolve Functional Heterogeneity in Mantle Cell Lymphoma. bioRxiv [Preprint] (2025). (under review at Science Advances) 

J. Yu, Y. Zhang , S. M. Duquette, G. L. Yee, T. Dinter, T. R. Usherwood, W. Wu, T. Miettinen, S. Spranger, S. R. Manalis, Bimodal cell mass distribution separates CD8+ T cells into two distinct types with divergent differentiation dynamics. bioRxiv [Preprint] (2024). (under review at Nature BME)

Y. Zhang, P. Zhang, L. Chen, A. Kaushik, K. Hu, T.-H. Wang, ddRFC: A scalable multiplexed droplet digital nucleic acid amplification test platform. Biosens. Bioelectron. (2020).

Y. Zhang, L. Chen, K. Hsieh, T.-H. Wang, Ratiometric Fluorescence Coding for Multiplex Nucleic Acid Amplification Testing. Anal. Chem. (2018). 

C. W. Beh, Y. Zhang, Y.-L. Zheng, B. Sun, T.-H. Wang, Fluorescence spectroscopic detection and measurement of single telomere molecules. Nucleic Acids Res. (2018).

Y. Zhang, Y. Zhang, J. M. Burke, K. Gleitsman, S. M. Friedrich, K. J. Liu, T.-H. Wang, A Simple Thermoplastic Substrate Containing Hierarchical Silica Lamellae for High Molecular Weight DNA Extraction. Adv. Mater. (2016). 

Visit Ye's Google Scholar for a full publication listing.

View Ye's CV.