Eli Vlaisavljevich, Ph.D.

Lab

Therapeutic Ultrasound and Noninvasive Therapies Laboratory

Watch this short video about the lab. All BEAM videos available here.

Research Areas

• Biomaterials
• Biomechanics
• Biomedical imaging
• Nanobioengineering
• Tissue Engineering
• Translational Cancer Research
  

Research Interests

• Therapeutic ultrasound (see a profile piece about his work, by Focused Ultrasound Foundation, here)
• Acoustic cavitation
• Non-invasive tissue ablation (histotripsy, HIFU)
• Nanoparticle-mediated histotripsy (NMH)
• Ultrasound-guided tissue regeneration
• Ultrasonic neuromodulation
• Medical device development

Education

• University of Michigan: Postdoctoral Researcher, Biomedical Engineering (20% Appointment), 2015-2017
  
• HistoSonics, Inc.: Product Development Engineer (80% Appointment), 2015-2017
  
• University of Michigan, Ph.D., Biomedical Engineering 2015
• University of Michigan, M.S., Biomedical Engineering 2013 
• Michigan Technological University: B.S.E, Biomedical Engineering, 2010 

Awards, Honors, and Service

• Kendall and Laura Hendrick Junior Faculty Fellow (College of Engineering)  2023
• Leader in Research Award (Department of Biomedical Engineering and Mechanics)  2023
• CoE Faculty Fellow Award (College of Engineering)  2023
• Outstanding Faculty Rising Star Award (State Council of Higher Education for Virginia)  2023
• Gold Pen Award (Department of Biomedical Engineering and Mechanics) 2022
• Elected to the Board of the International Society of Therapeutic Ultrasound (ISTU) 2021
• Outstanding Undergraduate Research Mentor Award (Office of Undergraduate Research) 2020
• Outstanding New Assistant Professor (College of Engineering) 2020
• Leader in Research Award (Department of Biomedical Engineering and Mechanics) 2020
• Gold Pen Award (Department of Biomedical Engineering and Mechanics) 2020
• Liviu Librescu Faculty Prize (VT BEAM) 2019
• Engineering Organization Advisor Award (Student Engineers’ Council) 2019
• Junior Faculty Award (Institute for Critical and Applied Technology) 2019
• Richard and Eleanor Towner Prize for Outstanding Ph.D. Research  2015
• NSF Graduate Research Fellowship  2010-2015

Selected Publications

Meyers K, Simon A, Khan Z, Rajachar R, Vlaisavljevich E. Focused ultrasound for the remote modulation of nitric oxide release from injectable PEG-fibrinogen hydrogels for tendon repair. Frontiers in Materials. (2023)

Khan Z, Wilts E, Vlaisavljevich E, Long T, Verbridge S. Development of a Synthetic, Injectable Hydrogel to Capture Residual Glioblastoma and Glioblastoma Stem‐Like Cells with CXCL12‐Mediated Chemotaxis. Advanced Healthcare Materials. (2023).

Ruger L, Hay A, Vickers E, Coutermarsh-Ott S, Gannon J, Covell H, Daniel G, Laeseke P, Ziemlewicz T, Kierski K, Ciepluch B, Vlaisavljevich E, Tuohy J. Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs. Cancers. (2023).

Stettinius A, Holmes H, Zhang Q, Mehochko I, Winters M, Hutchison R, Maxwell A, Holliday J, Vlaisavljevich E. DNA release from plant tissue using focused ultrasound extraction (FUSE). Applications in Plant Sciences. (2023).

Toydemir C, Hall S, Demirel E, Elmaci D, Gol D, Vlaisavljevich E, and Yuksel Durmaz Y. Bioconjugated β-Cyclodextrin–Perfluorohexane Nanocone Clusters as Functional Nanoparticles for Nanoparticle-Mediated Histotripsy. Biomacromolecules 23, no. 12 (2022).

Smolock AR, White SB, Rilling WS, Ziemlewicz TJ, Laeseke PF, Vlaisavljevich E, Xu Z, Lee FT. The Development of Histotripsy for the Treatment of Liver Tumors. Advances in Clinical Radiology. (2022).

Allen S, Fergusson A, Edsall C, Chen S, Moore D, Vlaisavljevich E, Davis R, Meyer C. IBCM Iron-based coupling media for MRI-guided ultrasound surgery. Medical Physics. (2022).

Toydemir C, Hall S, Demirel E, Elmaci D, Gol D, Vlaisavljevich E, Yuksel Durmaz Y. Bioconjugated β-Cyclodextrin-Perfluorohexane Nanocone Clusters as Functional Nanoparticles for Nanoparticle-Mediated Histotripsy. Biomacromolecules. (2022).

Stettinius A, Holmes H, Zhang Q, Mehochko I, Winters M, Hutchison R, Maxwell A, Holliday J, Vlaisavljevich E. Leaf DNA DNA release from plant tissue using focused ultrasound extraction (FUSE). Applications in Plant Sciences. (2022)

Vidal-Jove J, Serres X, Vlaisavljevich E, Cannata J, Duryea A, Miller R, Merino X, Velat M, Kam Y, Bolduan R, Amaral J, Hall T, Xu Z, Lee F, Ziemlewicz T. First-in-man histotripsy of hepatic tumors: the THERESA trial, a feasibility study. International Journal of Hyperthermia. (2022).

Visit Eli's Google Scholar for a full list of publications