Experimental and Computational Biomechanics of Ventricular Septation in the Chick Embryo

Wednesday, September 25, 2019

2:30 – 3:30pm

107 Surge Building, Virginia Tech Campus

Dr. Simone Rossi

Departments of Mathematics and Cell Biology & Physiology

University of North Carolina at Chapel Hill

Abstract:

Abnormal ventricular septation can lead to ventricular septal defects which account for up to 40% of all cardiac malformations occurring as a part in many congenital heart defects. Integrating experimental and computational approaches I investigate the influence of biomechanical factors on the development of the interventricular septum. The collected experimental data inform the development of a multiscale and multiphysics model of the chick embryonic heart. The hypothesis is that the coupled interaction between electrical conduction, contractility, and intracardiac flow dynamics cannot be separated when studying the biomechanics of the developing heart. Using imaging techniques on the chick embryo, I recreate a computational model of the embryonic heart. These computational models, used in combination with biological data on cell adaptation, have the potential to revolutionize the field of cardiac development and our understanding of congenital heart disease. In this talk, I will present some preliminary results on this ambitious project.

Biography:

Simone Rossi is a postdoctoral research associate at the University of North Carolina at Chapel Hill working in the Departments of Mathematics and Cell Biology & Physiology. His main interest lie in using mathematical and computational models of the heart for biological and medical research.

Simone Rossi received his bachelor and master degrees in Physics at the University of Milan (Italy). He received a joint PhD degree in Mathematics in 2014 from the Ecole Polytechnique Fédérale de Lausanne (Switzerland) and the Instituto Superior Tecnico de Lisboa (Portugal). He worked in the computational mechanics group at Duke University before joining UNC in 2016.