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Computational Modeling of Right Ventricular Intracardiac Flow in Repaired Tetralogy of Fallot

Wednesday, December 9, 2020

2:30pm – 3:45pm

Virtual via zoom (register by clicking here), Virginia Tech Campus

Elias Balaras

Department of Mechanical and Aerospace Engineering

George Washington University 


Patients with repaired Tetralogy of Fallot (rTOF) typically develop right ventricle (RV) dysfunction from chronic pulmonary insufficiency (PI) and eventually require pulmonary valve replacement (PVR). Despite the use of cardiac MRI (CMR) to guide therapy, current CMR methods do not predict patient-specific hemodynamic changes after PVR. In this study, we demonstrate a method that uses conventional non-invasive CMR imaging and a unique modeling tool to simulate the intracardiac flow in an rTOF patient to predict changes after PVR. CMR datasets from patients and age-matched volunteers were used to create a kinematic representation of the RV through the entire cardiac cycle by means of diffeomorphic mapping techniques. The RV kinematic model was then fed into an in-house CFD solver based on a robust immersed boundary method, which carried out fully-resolved direct numerical simulations over several cardiac cycles. The results will show significant flow differences between the rTOF patient and volunteer control, including vorticity, kinetic energy and pumping efficiency. This computational framework will lead to better clinical indications of PVR, an important aspect in the long-term care of rTOF patients.


Elias Balaras is a Professor in the Department of Mechanical and Aerospace Engineering at the George Washington University. He received his Ph.D. from EPFL in Lausanne in 1995. He was formerly a visiting scientist at NIST and a faculty member at the University of Maryland. He has been a faculty member at the George Washington University since January 2011. Prof. Balaras has received several awards including the Marie-Curie fellowship from the European Commission in 1994 and the CAREER award from NSF in 2003. Dr. Balaras has published over 150 papers in refereed journals and conference proceedings. He is currently an associate editor at the ASME J. Fluids Eng. and served as reviewer for numerous government programs related to fluid mechanics, biological flows, high performance computing and turbulence.